An inhibitor of Cdk9/cyclin T1
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Atuveciclib

Item No. 44337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(+)-4-(4-fluoro-2-methoxyphenyl)-N-[3-[(S-methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine
CAS Number
1414943-94-4
Synonyms
  • BAY-1143572
Molecular Formula
C18H18FN5O2S
Formula Weight
387.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CS(CC1=CC=CC(NC2=NC(C3=C(OC)C=C(C=C3)F)=NC=N2)=C1)(=N)=O
InChi Code
InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24)
InChi Key
ACWKGTGIJRCOOM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $274

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    10 mg

    $493

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    25 mg

    $822

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    50 mg

    $1,370

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    Product Description

    Atuveciclib is an inhibitor of Cdk9/cyclin T1 (IC50 = 6 nM).1 It is selective for Cdk9/cyclin T1 over Cdk1/cyclin B, Cdk2/cyclin E, Cdk3/cyclin E, Cdk5/p35, Cdk6/cyclin D3, and Cdk7/cyclin H/Mat1 (IC50s = 1,100, 1,000, 890, 1,600, >10,000 and >10,000 nM, respectively). In vivo, atuveciclib (6.25 and 12.5 mg/kg) reduces tumor area in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model. It reduces skin thickness and scaling in a mouse model of psoriasis induced by imiquimod (Item No. 14956).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lücking, U., Scholz, A., Lienau, P., et al. Identification of atuveciclib (BAY 1143572), the first highly selective, clinical PTEFb/CDK9 inhibitor for the treatment of cancer. ChemMedChem 12(21), 1776-1793 (2017).

    2. Zhao, F., Wang, Y., Zuo, H., et al. Cyclin-dependent kinase 9 (CDK9) inhibitor atuveciclib ameliorates imiquimod-induced psoriasis-Like dermatitis in mice by inhibiting various inflammation factors via STAT3 signaling pathway. Int. Immunopharmacol. 129, 111652 (2024).