A thiocarbamate antifungal agent
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Liranaftate

Item No. 44439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-methoxy-2-pyridinyl)-N-methyl-carbamothioic acid, O-(5,6,7,8-tetrahydro-2-naphthalenyl) ester
CAS Number
88678-31-3
Synonyms
  • M-732
  • Piritetrate
Molecular Formula
C18H20N2O2S
Formula Weight
328.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CN(C(OC1=CC=C2CCCCC2=C1)=S)C3=NC(OC)=CC=C3
InChi Code
InChI=1S/C18H20N2O2S/c1-20(16-8-5-9-17(19-16)21-2)18(23)22-15-11-10-13-6-3-4-7-14(13)12-15/h5,8-12H,3-4,6-7H2,1-2H3
InChi Key
VPHPQNGOVQYUMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    Liranaftate is a thiocarbamate antifungal agent.1 It is active against T. rubrum (MIC = 0.009 g/ml).1 Liranaftate inhibits lung epithelial cell ferroptosis and malondialdehyde (MDA) production and reduces lung IL-6, IL-1β, and TNF-α levels in a mouse model of acute lung injury induced by paraquat (Item No. 38521).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Oku, Y., Sakuma, K., Yokoyama, K., et al. Fungicidal activity of liranaftate against Trichophyton rubrum. Nihon Ishinkin Gakkai Zasshi 43(3), 181-187 (2002).

    2. Zhu, Y., Zhao, W., Li, W., et al. Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis. J. Adv. Res. S2090-1232(2025)00385-00386 (2025).