A quinolone antibiotic
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Rosoxacin

Item No. 44519

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridinyl)-3-quinolinecarboxylic acid
CAS Number
40034-42-2
Synonyms
  • WIN 35,213
Molecular Formula
C17H14N2O3
Formula Weight
294.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CN(CC)C2=C(C1=O)C=CC(C3=CC=NC=C3)=C2)O
InChi Code
InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
InChi Key
XBPZXDSZHPDXQU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $396

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    50 mg

    $693

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    Product Description

    Rosoxacin is a quinolone antibiotic.1 It is active against C. jejuni, S. boydii, S. dysenteriae, V. cholerae, and Y. enterocolitica (MIC50s = ≤0.25 mg/L for all). Rosoxacin (10 µM) inhibits IL-1 receptor-associated kinase 1 (IRAK-1) in vitro and suppresses the development of murine growth hormone-induced experimental autoimmune hypophysitis (EAH) in mice when administered at a dose of 200 µg/animal per day.2 Formulations containing rosoxacin have been used in the treatment of urinary tract infections and sexually transmitted diseases (STDs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vanhoof, R., Hubrechts, J.M., Roebben, E., et al. The comparative activity of pefloxacin, enoxacin, ciprofloxacin and 13 other antimicrobial agents against enteropathogenic microorganisms. Infection 14(6), 294-298 (1986).

    2. Huang, H.C., Chen, Y.T., Lin, H.H., et al. Inhibition of IRAK1 is an effective therapy for autoimmune hypophysitis in mice. Int. J. Mol. Sci. 23(23), 14958 (2022).