A synthetic flavonoid with diverse biological activities
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Recoflavone

Item No. 44582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-(3,4-dimethoxyphenyl)-5-methoxy-4-oxo-4H-1-benzopyran-7-yl]oxy] acetic acid
CAS Number
203191-10-0
Synonyms
  • 7-Carboxymethyloxy-3′,4′,5-trimethoxyflavone
  • DA-6034
Molecular Formula
C20H18O8
Formula Weight
386.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(COC(C=C1OC(C2=CC(OC)=C(OC)C=C2)=C3)=CC(OC)=C1C3=O)O
InChi Code
InChI=1S/C20H18O8/c1-24-14-5-4-11(6-16(14)25-2)15-9-13(21)20-17(26-3)7-12(8-18(20)28-15)27-10-19(22)23/h4-9H,10H2,1-3H3,(H,22,23)
InChi Key
BCPQOBQIVJZOFL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $270

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    Cayman Chemical
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    Product Description

    Recoflavone is a synthetic flavonoid with diverse biological activities and a derivative of eupatilin (Item No. 19601).1,2,3,4 It induces chloride currents and intracellular calcium release in primary human conjunctival epithelial cells when used at concentrations of 10 and 100 µM, respectively.1 Recoflavone (10 and 100 µM) induces the migration of AGS and SNU-484 human gastric epithelial cells in a scratch assay in an in vitro model of gastric ulcer healing.2 In vivo, recoflavone (50 mg/kg) decreases body weight gain rate, liver weight and triglyceride levels, and hepatic macrophage and CD8+ T cell infiltration in a mouse model of obesity induced by a high-fat diet.3 Recoflavone (30 mg/kg) decreases disease severity, increases colon length, and increases survival in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).4 It also inhibits azoxymethane- and DSS-induced carcinogenesis in a mouse model of colitis-associated cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Y.M., Park, S., Ji, H., et al. DA-6034 induces [Ca2+]i increase in epithelial cells. Korean J. Physiol. Pharmacol. 18(2), 89-94 (2014).

    2. Kim, Y.W., Lee, W.H., Choi, S.M., et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. J. Gastroenterol. Hepatol. 27(2), 397-405 (2012).

    3. Kim, H.M., Kwon, M.-H., Lee, E.S., et al. DA-6034 ameliorates hepatic steatosis and inflammation in high fat diet-induced obese mice. J. Yeungnam Med. Sci. 41(2), 103-112 (2024).

    4. Nam, S.Y., Kim, J.S., Kim, J.M., et al. DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp. Biol. Med. (Maywood) 233(2), 180-191 (2008).