A triterpene with diverse biological activities
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Polyporenic Acid C

Item No. 44639

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
16α-hydroxy-24-methylene-3-oxo-lanosta-7,9(11)-dien-21-oic acid
CAS Number
465-18-9
Molecular Formula
C31H46O4
Formula Weight
482.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@@H](C1)O)(CC=C3C2=CC[C@]4([H])[C@@]3(CCC(C4(C)C)=O)C)C
InChi Code
InChI=1S/C31H46O4/c1-18(2)19(3)9-10-20(27(34)35)26-23(32)17-31(8)22-11-12-24-28(4,5)25(33)14-15-29(24,6)21(22)13-16-30(26,31)7/h11,13,18,20,23-24,26,32H,3,9-10,12,14-17H2,1-2,4-8H3,(H,34,35)/t20-,23-,24+,26+,29-,30-,31+/m1/s1
InChi Key
KPKYWYZPIVAHKU-WMNQUVFJSA-N
Origin
Fungus/Wolfiporia cocos (Schw.) Ryv.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $235

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    10 mg

    $400

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    25 mg

    $705

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    50 mg

    $1,058

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Polyporenic acid C is a triterpene that has been found in P. cocos and has diverse biological activities.1,2,3 It is active against M. phlei and M. smegmatis when used at concentrations ranging from 0.78 to 2 µg/ml.1 Polyporenic acid C (20, 60, and 80 µM) induces apoptosis in A549 lung cancer cells.2 In vivo, polyporenic acid C (25 and 50 mg/kg) reduces hepatic lipid accumulation and inguinal white adipose tissue mitochondrial degeneration and increases the inguinal brown adipose tissue index in a mouse model of high-fat diet-induced steatosis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marcus, S. Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr. Biochem J. 50(4), 516-517 (1952).

    2. Ling, H., Zhou, L., Jia, X., et al. Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells. Mol. Carcinog. 48(6), 498-507 (2009).

    3. He, X., Tao, Y., Song, C., et al. Novel Parkin agonists from Poria cocos against dyslipidemia. Fitoterapia 182, 106469 (2025).