A VRK1 inhibitor
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VRK-IN-1

Item No. 44649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4'-(2-methylpyridine-3,5-diyl)bis(2,6-difluorophenol)
CAS Number
2378855-09-3
Synonyms
  • Vaccinia-related Kinase 1-IN-1
  • Vaccinia-related Kinase-1 Inhibitor 1
  • VRK Inhibitor 1
Molecular Formula
C18H11F4NO2
Formula Weight
349.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Slightly soluble: 0.1-1 mg/ml
SMILES
FC1=CC(C2=CN=C(C)C(C3=CC(F)=C(O)C(F)=C3)=C2)=CC(F)=C1O
InChi Code
InChI=1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3
InChi Key
PMRGRXLXKYUDIH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $185

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    10 mg

    $293

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    25 mg

    $488

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    Product Description

    VRK-IN-1 is an inhibitor of vaccinia-related kinase 1 (VRK1; IC50 = 150 nM).1 It is selective for VRK1 over a panel of 48 additional kinases at 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Serafim, R.A.M., de Souza Gama, F.H., Dutra, L.A., et al. Development of pyridine-based inhibitors for the human vaccinia-related kinases 1 and 2. ACS Med. Chem. Lett. 10(9), 1266-1271 (2019).