A biotinylated Akt (phospho-Ser473) peptide
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Akt (Phospho-Ser473)-biotin Peptide (trifluoroacetate salt)

Item No. 44665

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoyl)-L-arginyl-L-arginyl-L-prolyl-L-histidyl-L-phenylalanyl-L-prolyl-L-glutaminyl-L-phenylalanyl-O-phosphono-L-seryl-L-tyrosyl-L-seryl-L-alanyl-L-serylglycyl-L-threonyl-L-alanine, trifluoroacetate salt
Synonyms
  • Biotin-Akt (Phospho-Ser473) Peptide
  • PKB (Phospho-Ser473)-biotin Peptide
  • Protein Kinase B (Phospho-Ser473)-biotin Peptide
  • RAC-PK (Phospho-Ser473)-biotin Peptide
  • RAC Serine/threonine-protein Kinase (Phospho-Ser473)-biotin Peptide
Molecular Formula
C91H132N27O28PS • XCF3COOH
Formula Weight
2115.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Biotin-RRPHFPQF-pS-YSASGTA-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
OC([C@@H](NC([C@@]([C@H](O)C)([H])NC(CNC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](COP(O)(O)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CCCC[C@H]3[C@@]4([H])NC(N[C@]4(CS3)[H])=O)=O)=O)=O)=O)CC5=CN=CN5)=O)CC6=CC=CC=C6)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC(C=C8)=CC=C8O)=O)=O)C)=O)=O)=O)=O)C)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C91H132N27O28PS.C2HF3O2/c1-47(74(126)111-62(42-119)75(127)100-41-71(125)115-72(49(3)121)85(137)103-48(2)88(140)141)102-81(133)63(43-120)112-78(130)59(37-52-26-28-54(122)29-27-52)108-82(134)64(44-146-147(143,144)145)113-79(131)58(36-50-16-6-4-7-17-50)107-77(129)56(30-31-69(92)123)105-83(135)66-22-15-35-118(66)87(139)61(38-51-18-8-5-9-19-51)110-80(132)60(39-53-40-97-46-101-53)109-84(136)67-23-14-34-117(67)86(138)57(21-13-33-99-90(95)96)106-76(128)55(20-12-32-98-89(93)94)104-70(124)25-11-10-24-68-73-65(45-148-68)114-91(142)116-73;3-2(4,5)1(6)7/h4-9,16-19,26-29,40,46-49,55-68,72-73,119-122H,10-15,20-25,30-39,41-45H2,1-3H3,(H2,92,123)(H,97,101)(H,100,127)(H,102,133)(H,103,137)(H,104,124)(H,105,135)(H,106,128)(H,107,129)(H,108,134)(H,109,136)(H,110,132)(H,111,126)(H,112,130)(H,113,131)(H,115,125)(H,140,141)(H4,93,94,98)(H4,95,96,99)(H2,114,116,142)(H2,143,144,145);(H,6,7)/t47-,48-,49+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,72-,73-;/m0./s1
InChi Key
PLRKIHFIBHICHV-DQZBASKJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $158

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    Product Description

    Akt (phospho-Ser473)-biotin peptide is a biotinylated peptide corresponding to amino acids 465 to 480 of Akt1. Akt, also known as protein kinase B (PKB), is a serine/threonine kinase belonging to the AGC kinase family and has three isoforms in mammals: Akt1, Akt2, and Akt3.1,2 Akt kinases function downstream of activated tyrosine kinases and PI3K to regulate a variety of cellular processes, including cell size, growth, proliferation, and survival, as well as genome stability, glucose metabolism, and neovascularization.2 Akt is activated following phosphorylation at threonine 308, 309, and 305 and serine 473, 474, and 472 for Akt1, -2, and -3, respectively.3 This product can be used in the detection of antibodies targeting Akt (phospho-Ser473) in biological samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dummler, B., and Hemmings, B.A. Physiological roles of PKB/Akt isoforms in development and disease. Biochem. Soc. Trans. 35(Pt 2), 231-235 (2007).

    2. Bellacosa, A., Kumar, C.C., Di Cristofano, A., et al. Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv. Cancer Res. 94, 29-86 (2005).

    3. Santi, S.A., and Lee, H. The Akt isoforms are present at distinct subcellular locations. Am. J. Physiol. Cell Physiol. 298(3), C580-C591 (2010).