A ROCK inhibitor intended for use in cell, gene, and tissue engineering applications
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GMP Y-27632 (hydrochloride) Ancillary Material

Item No. 44675

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[(1R)-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide, dihydrochloride
CAS Number
129830-38-2
Molecular Formula
C14H21N3O • 2HCl
Formula Weight
320.3
Purity
≥98%
Formulation
An amorphous solid
SMILES
O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.Cl.Cl
InChi Code
InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
InChi Key
IDDDVXIUIXWAGJ-LJDSMOQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $1,250

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    Product Description

    Y-27632 is a potent, ATP-competitive inhibitor of ROCKs.1 In cell and gene engineering applications, it has been shown to facilitate cell proliferation, migration, differentiation, and viability.2

    This product has been manufactured and tested in accordance with GMP principles set forth by the ICH and FDA and meets the expectations for commercial cell, gene, and tissue-engineered products in accordance with USP <1043> "Ancillary Materials for Cell, Gene, and Tissue-engineered Products.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351(1), 95-105 (2000).

    2.  &lt;1043> Ancillary materials for cell, gene, and tissue-engineered products. (2025).