A ROCK inhibitor intended for use in cell, gene, and tissue engineering applications
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Y-27632 (hydrochloride) Ancillary Material

Item No. 44885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[(1R)-1-aminoethyl]-N-4-pyridinyl-cyclohexanecarboxamide, dihydrochloride
CAS Number
129830-38-2
Molecular Formula
C14H21N3O • 2HCl
Formula Weight
320.3
Purity
≥98%
Formulation
An amorphous solid
SMILES
O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2.Cl.Cl
InChi Code
InChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
InChi Key
IDDDVXIUIXWAGJ-LJDSMOQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $1,099

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    Product Description

    Y-27632 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs).1 It has been used to enhance cell survival and cloning efficiency, as well as to prevent dissociation-induced apoptosis, also known as anoikis, in pluripotent stem cells.2,3,4 Y-276932 (hydrochloride) Ancillary Material is intended for use in cell, gene, and tissue engineering applications.

    This product has been tested in accordance with GMP principles and meets the expectations for clinical cell, gene, and tissue-engineered products in accordance with USP <1043> “Ancillary Materials for Cell, Gene, and Tissue-engineered Products”.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351(1), 95-105 (2000).

    2. Wang, X., Lin, G., Martins-Taylor, K., et al. Inhibition of caspase-mediated anoikis is critical for basic fibroblast growth factor-sustained culture of human pluripotent stem cells. The Journal of Biological Chemisty 284(49), 34054-34064 (2009).

    3. Gandham, V.D., Maddala, R.L., Rao, V., et al. Effects of Y27632 on keratinocyte procurement and wound healing. Clin. Exp. Dermatol. 38(7), 782-786 (2013).

    4. Fuentes, E.O., Leemhuis, J., Stark, G.B., et al. Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells. J. Brachial Plex. Peripher. Nerve Inj. 3(19), (2008).

    5.  &lt;1043> Ancillary materials for cell, gene, and tissue-engineered products. (2025).