For immunochemical detection of MMAE conjugates
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MMAE Monoclonal Antibody (Clone 1G1)

Item No. 44706

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Monomethyl Auristatin E
  • Vedotin
Immunogen
Vc-MMAE-KLH
Clone Designation
1G1
Formulation (Request formulation change)
100 µg of protein G-purified monoclonal antibody
Storage Buffer
PBS (pH 7.2), with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG3k
Applications
ELISA, WB
Cross Reactivity
(+++) MMAE(+) Mertansine
Species Reactivity
(+) Species independent
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $399

    Add
    Cayman Chemical
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    Product Description

    Monomethyl auristatin E (MMAE) is an inhibitor of tubulin polymerization and a derivative of dolastatin 10.1 It inhibits the assembly of MAP-rich tubulin and induces cell cycle arrest and cell death in cancer cells in vitro.2 MMAE has been used as the cytotoxic payload component of antibody-drug conjugates (ADCs) with anticancer activity in vitro and in animal models.2,1 Cayman’s MMAE Monoclonal Antibody (Clone 1G1) can be used for ELISA and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Best, R.L., LaPointe, N.E., Azarenko, O., et al. Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy. Toxicol. Appl. Pharmacol. 421, 115534 (2021).

    2. Francisco, J.A., Cerveny, C.G., Meyer, D.L., et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 102(4), 1458-1465 (2003).