For immunochemical detection of exatecan conjugates
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Alternative(s)
45399Exatecan Polyclonal Antibody
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Exatecan Monoclonal Antibody (Clone 1B2)

Item No. 44715

Product Insert (PDF)
Technical Information
Synonyms
  • DX 8951f
Immunogen
Exatecan-KLH
Clone Designation
1B2
Formulation (Request formulation change)
100 µg of protein G-purified monoclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Mouse
Isotype
IgG2aK
Applications
ELISA, WB
Cross Reactivity
(+) Exatecan and deruxtecan(-) Other warheads
Species Reactivity
(+) Species independent
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $320

    Add
    Cayman Chemical
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    Product Description

    Exatecan is a DNA topoisomerase I inhibitor that inhibits cancer cell growth in vitro and reduces tumor growth in vivo.1,2 It has been used as the cytotoxic payload component of antibody-drug conjugates (ADCs), which have been used to selectively target and destroy cancer cells in vitro and in vivo in animal models.3,4 Cayman’s Exatecan/Deruxtecan Monoclonal Antibody (Clone 1B2) can be used for ELISA and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mitsui, I., Kumazawa, E., Hirota, Y., et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn. J. Cancer Res. 86(8), 776-782 (1995).

    2. Kumazawa, E., and Ochi, Y. DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f: Potent antitumor activities in various murine tumor models. Cancer Sci. 95(2), 168-175 (2004).

    3. Conilh, L., Fournet, G., Fourmaux, E., et al. Exatecan antibody drug conjugates based on a hydrophilic polysarcosine drug-linker platform. Pharmaceuticals (Basel) 14(3), 247 (2021).

    4. Ianniello, Z., Lu, H., Quijano, E., et al. Harnessing AxDNA for precision exatecan delivery in cancer: A novel antibody-drug conjugate approach. Mol. Cancer 24(1), 253 (2025).