An inhibitor of SPNS2
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SLF80821178 (trifluoroacetate salt)

Item No. 44781

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-decylphenyl)-1-piperazinecarboxamide
Molecular Formula
C21H35N3O • CF3COOH
Formula Weight
459.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N1CCNCC1)NC2=CC=C(CCCCCCCCCC)C=C2.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C21H35N3O.C2HF3O2/c1-2-3-4-5-6-7-8-9-10-19-11-13-20(14-12-19)23-21(25)24-17-15-22-16-18-24;3-2(4,5)1(6)7/h11-14,22H,2-10,15-18H2,1H3,(H,23,25);(H,6,7)
InChi Key
DHHBJYQELNRRQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $196

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    10 mg

    $319

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    Product Description

    SLF80821178 is an inhibitor of the sphingosine-1-phosphate transporter (SPNS2).1 It reduces sphingosine-1-phosphate (S1P) secretion in HeLa cells with an IC50 value of 51 nM. Oral administration of SLF80821178 (100 mg/kg) decreases the number of circulating lymphocytes in mice, without reducing plasma S1P concentration. It reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by MOG35-55 (Item No. 35644) when administered at doses of 10 and 30 mg/kg per day.2 Unlike the loss of Spns2 function in Spns2-/- mice, inhibition of Spns2 by SLF80821178 does not induce neurosensorial hearing defects.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Foster, D.J., Dunnavant, K., Shrader, C.W., et al. Discovery of potent, orally bioavailable sphingosine-1-phosphate transporter (Spns2) inhibitors. J. Med. Chem. 67(13), 11273-11295 (2024).

    2. Kharel, Y., Huang, T., Dunnavant, K., et al. Assessment of Spinster homologue 2 (Spns2)-dependent transport of sphingosine-1-phosphate as a therapeutic target. Br. J. Pharmacol. 182(9), 2014-2030 (2025).