An internal standard for the quantification of substance P
Related Products
Unlabeled Version(s)
24035Substance P (trifluoroacetate salt)
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Substance P-d10 (trifluoroacetate salt)

Item No. 44814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-(methyl-d3)-1-oxopentan-2-yl-2,3,3,4,5,5,5-d7)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide, trifluoroacetate salt
Synonyms
  • SP-d10
Molecular Formula
C63H88D10N18O13S • XCF3COOH
Formula Weight
1357.7
Purity
≥99% deuterated forms (d1-d10)
Formulation (Request formulation change)
A solid
Peptide Sequence
RPKPQQFFGLM-NH2-d10
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NCC(NC(C(N[C@H](C(N)=O)CCSC)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)[C@H]4N(C([C@@H](N)CCCNC(N)=N)=O)CCC4.O=C(C(F)(F)F)O
InChi Code
InChI=1S/C63H98N18O13S.C2HF3O2/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;3-2(4,5)1(6)7/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);(H,6,7)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-;/m0./s1/i1D3,2D3,33D2,37D,45D;
InChi Key
HJUBUMANGKVTGH-BMKPXLGZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    Product Description

    Substance P-d10 is intended for use as an internal standard for the quantification of substance P (Item No. 24035) by GC- or LC-MS. Substance P is a tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities.1,2 It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system, and in immune cells.2 Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK1 receptors.3 The NK1 receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia.4 Substance P is also involved in depression, anxiety, seizures, and emesis, among other functions.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gether, U., Johansen, T.E., Snider, R.M., et al. Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist. Nature 362(6418), 345-348 (1993).

    2. Muñoz, M., and Coveñas, R. Involvement of substance P and the NK-1 receptor in human pathology. Amino Acids 46(7), 1727-1750 (2014).

    3. Mantyh, P.H. Neurobiology of substance P and the NK1 receptor. J. Clin. Psychiatry 63(Suppl 11), 6-10 (2002).

    4. Abbadie, C., Trafton, J., Mantyh, P.W., et al. Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J. Neurosci. 17(20), 8049-8060 (1997).