A KATP channel inhibitor
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PNU 37883 (hydrochloride)

Item No. 44821

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-cyclohexyl-N′-tricyclo[3.3.1.1 ]dec-1-yl-4-morpholinecarboximidamide, monohydrochloride
CAS Number
57568-80-6
Synonyms
  • PNU 37883A
  • U-37883A
Molecular Formula
C21H35N3O • HCl
Formula Weight
382.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
C(NC1CCCCC1)(N2CCOCC2)=NC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3.Cl
InChi Code
InChI=1S/C21H35N3O.ClH/c1-2-4-19(5-3-1)22-20(24-6-8-25-9-7-24)23-21-13-16-10-17(14-21)12-18(11-16)15-21;/h16-19H,1-15H2,(H,22,23);1H/t16-,17+,18-,21?;
InChi Key
FZALCKUJYZCDOX-ANWXTAAGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $35

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    5 mg

    $166

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    10 mg

    $210

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    Product Description

    PNU 37883 is an inhibitor of ATP-sensitive potassium (KATP) channels.1 It inhibits sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) and SUR2B/Kir6.1 (IC50s = 15.2 and 6 µM, respectively) and SUR1/Kir6.2 and SUR2A/Kir6.2 to a lesser extent at 100 µM. PNU 37883 (0.1 and 0.3 µM) inhibits relaxation of isolated rat middle meningeal arteries induced by pinacidil (Item No. 15416), levcromakalim, or P1075 (Item No. 21849).2 It increases kallikrein secretion from microdissected connecting tubules isolated from normotensive and spontaneously hypertensive rats.3 PNU 37883 (15 mg/kg) increases sodium excretion and does not affect potassium excretion or glomerular filtration rate in saline-loaded rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cui, Y., Tinker, A., and Clapp, L.H. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br. J. Pharmacol. 139(1), 122-128 (2003).

    2. Ploug, K.B., Boni, L.J., Baun, M., et al. KATP channel expression and pharmacological in vivo and in vitro studies of the KATP channel blocker PNU-37883A in rat middle meningeal arteries. Br. J. Pharmacol. 154(1), 72-81 (2008).

    3. Yamanaka, M., Hayashi, I., Fujita, T., et al. Potassium-induced increase in renal kallikrein secretion is attenuated in dissected renal connecting tubules of young spontaneously hypertensive rats. Int. Immunopharmacol. 2(12-14), 1957-1964 (2002).

    4. Ludens, J.H., Clark, M.A., and Lawson, J.A. Effects of a K+ channel blocker on glomerular filtration rate and electrolyte excretion in conscious rats. J. Pharmacol. Exp. Ther. 273(3), 1375-1381 (1995).