An inhibitor of Tyro3
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UNC9426

Item No. 44849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[2-[[3,5-bis(trifluoromethyl)phenyl]amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol
CAS Number
3051784-94-9
Molecular Formula
C32H34F6N6O
Formula Weight
632.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(C1=CC(NC2=NC=C3C(C4=CC=C(CN5CCN(CC5)C)C=C4)=CN(C3=N2)[C@@H]6CC[C@H](CC6)O)=CC(C(F)(F)F)=C1)F
InChi Code
InChI=1S/C32H34F6N6O/c1-42-10-12-43(13-11-42)18-20-2-4-21(5-3-20)28-19-44(25-6-8-26(45)9-7-25)29-27(28)17-39-30(41-29)40-24-15-22(31(33,34)35)14-23(16-24)32(36,37)38/h2-5,14-17,19,25-26,45H,6-13,18H2,1H3,(H,39,40,41)/t25-,26-
InChi Key
CPWDPNAAVHWMCG-DIVCQZSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    Product Description

    UNC9426 is an inhibitor of the TAM family kinase Tyro3 (IC50 = 2.1 nM).1 It is selective for Tyro3 over MerTK and Axl (IC50s = 580 and 190 nM, respectively) and 74 other kinases in a panel at 1 µM. UNC9426 (10 µM) reduces ADP- or collagen-induced platelet aggregation in isolated human platelet-rich plasma. It does not increase total bleeding time in mice after tail tip transection when administered at a dose of 10 mg/kg. UNC9426 also reduces the uptake of phosphatidylserine-coated microparticles, a model of apoptotic cells, by THP-1 macrophages in an efferocytosis assay in a concentration-dependent manner and reduces colony formation in NCI H1650 or H1975 non-small cell lung cancer (NSCLC) cells (EC50s = 170 and 197 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kong, D., Yang, X., Judd, S., et al. UNC9426, a potent and orally bioavailable TYRO3-specific inhibitor. J. Med. Chem. 68(6), 665-6682 (2025).