An SM-102-based LNP solution for expressing naked mole-rat cGAS
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Alternative(s)
44930LipidLaunch™ SM-102 LNP (human cGAS)
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LipidLaunch™ SM-102 LNP (naked mole-rat cGAS)

Item No. 44929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation (Request formulation change)
TBS, pH 7.5, with 10% sucrose
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 µg

    $499

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    Cayman Chemical
    Product Description

    LipidLaunch™ SM-102 LNP (naked mole-rat cGAS) is a solution containing lipid nanoparticles (LNPs) composed of the ionizable cationic aminolipid SM-102 (Item No. 33474), cholesterol (Item No. 9003100), 1,2-distearoyl-sn-glycero-3-PC (1,2-DSPC; Item No. 15100), and the lipid excipient DMG-PEG(2000) (Item No. 33945) at a molar ratio of 50:38.5:10:1.5 and encapsulating mRNA encoding His-tagged naked mole-rat cyclic GMP-AMP (cGAMP) synthase (cGAS), a nucleotidyltransferase involved in the innate immune response.1,2 It is intended for overexpression of His-tagged naked mole-rat cGAS in vitro and can be used in a variety of model cell lines. Administration of a recombinant adeno-associated viral (AAV) vector encoding naked mole-rat cGAS increases lifespan in Drosophila and decreases frailty index and hair greying in mice.3

    Suggested in vitro use: Thaw LNPs on ice with occasional gentle swirling (do not vortex). Using a gentle pipetting technique, dilute 1:100-1:500 in complete cell culture media (with serum) and add to subconfluent cells. Expression of His-tagged naked mole-rat cGAS may be detected between six and 48 hours after transfection. Optimal conditions are highly dependent on cell type.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, L., Wu, J., Du, F., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121), 786-791 (2013).

    2. Wu, J., Sun, L., Chen, X., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121), 826-830 (2013).

    3. Chen, Y., Chen, Z., Wang, H., et al. A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. Science 390(6769), eadp5056 (2025).