An NMDA receptor antagonist and active metabolite of BHV 5000
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Lanicemine (hydrochloride)

Item No. 44983

Product Insert (PDF)
Technical Information
Formal Name
α-phenyl-2-pyridineethanamine, dihydrochloride
CAS Number
153322-06-6
Synonyms
  • ARL 15896AR
  • AR-R 15896AR
  • AZD 6765
  • BHV 5500
Molecular Formula
C13H14N2 • 2HCl
Formula Weight
271.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
N[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl
InChi Code
InChI=1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
InChi Key
KHJHFYAGQZYCLC-GXKRWWSZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $58

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    10 mg

    $104

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    25 mg

    $218

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    50 mg

    $348

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    Product Description

    Lanicemine is a low-trapping NMDA receptor antagonist (IC50 = 9.8 µM) and an active metabolite of BHV 5000.1,2 Intraperitoneal administration of lanicemine prevents seizures induced by maximal electroshock, 4-aminopyridine (Item No. 18511), N-methyl-DL-aspartate, or kainic acid in mice (ED50s = 13, 17.1, 54, and ~50 mg/kg, respectively).3 Lanicemine (24 mg/kg, p.o.) decreases hippocampal neuronal damage in a rat model of global ischemia induced by four-vessel occlusion.4 It decreases immobility time in the tail suspension test in mice, an effect that is enhanced by hyperforin (Item No. 19572).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mealing, G.A., Lanthorn, T.H., Small, D.L., et al. Antagonism of N-methyl-ᴅ-aspartate-evoked currents in rat cortical cultures by ARL 15896AR. J. Pharmacol. Exp. Ther. 281(1), 376-383 (1997).

    2. Henter, I.D., Park, L.T., and Zarate, C.A., Jr. Novel glutamatergic modulators for the treatment of mood disorders: Current status. CNS Drugs 35(5), 527-543 (2021).

    3. Palmer, G.C., Murray, R.J., Cramer, C.L., et al. [S]-AR-R 15896AR—a novel anticonvulsant: Acute safety, pharmacokinetic and pharmacodynamic properties. J. Pharmacol. Exp. Ther. 288(1), 121-132 (1999).

    4. Cregan, E.F., Peeling, J., Corbett, D., et al. [(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride], a low affinity uncompetitive N-methyl-ᴅ-aspartic acid antagonist, is effective in rodent models of global and focal ischemia. J. Pharmacol. Exp. Ther. 283(3), 1412-1424 (1997).

    5. Pochwat, B., Szewczyk, B., Kotarska, K., et al. Hyperforin potentiates antidepressant-like activity of lanicemine in mice. Front. Mol. Neurosci. 11, 456 (2018).