An internal standard for the quantification of enzalutamide
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Unlabeled Version(s)
11596Enzalutamide
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Enzalutamide-d3

Item No. 45044

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-(methyl-d3)-benzamide
CAS Number
1443331-82-5
Molecular Formula
C21H13D3F4N4O2S
Formula Weight
467.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleEthyl Acetate: Slightly soluble
SMILES
S=C1N(C2=CC(F)=C(C=C2)C(NC([2H])([2H])[2H])=O)C(C)(C(N1C3=CC(C(F)(F)F)=C(C=C3)C#N)=O)C
InChi Code
InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)/i3D3
InChi Key
WXCXUHSOUPDCQV-HPRDVNIFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $385

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    Product Description

    Enzalutamide-d3 is intended for use as an internal standard for the quantification of enzalutamide (Item No. 11596) by GC- or LC-MS. Enzalutamide is a non-steroidal androgen receptor antagonist (IC50 = 36 nM).1,2 It reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators.1 It is orally available and induces tumor regression in mouse models of castration-resistant human prostate cancer.1 Formulations containing enzalutamide have been used in the treatment of prostate cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tran, C., Ouk, S., Clegg, N.J., et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324(5928), 787-790 (2009).

    2. Jung, M.E., Ouk, S., Yoo, D., et al. Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC). J. Med. Chem. 53(7), 2779-2796 (2010).