A DPP-4 inhibitor
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Cofrogliptin

Item No. 45049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-amino-2,6-anhydro-1,3,4,5-tetradeoxy-6-C-(2,5-difluorophenyl)-3-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-cpyrazol-5(4H)-yl]-1,1,1-trifluoro-D-arabino-hexitol
CAS Number
1844874-26-5
Synonyms
  • HSK7653
Molecular Formula
C18H19F5N4O3S
Formula Weight
466.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
FC(C=CC(F)=C1)=C1[C@H]([C@H](C2)N)O[C@H](C(F)(F)F)[C@@H]2N3CC4=CN(S(C)(=O)=O)N=C4C3
InChi Code
InChI=1S/C18H19F5N4O3S/c1-31(28,29)27-7-9-6-26(8-14(9)25-27)15-5-13(24)16(30-17(15)18(21,22)23)11-4-10(19)2-3-12(11)20/h2-4,7,13,15-17H,5-6,8,24H2,1H3/t13-,15+,16+,17-/m0/s1
InChi Key
GUBOXFWNNXSQNH-SVGFKBNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $325

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Cofrogliptin is a long-acting inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 10.8 nM).1 It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = >100 µM for both) and a panel of 127 receptors, ion channels, transporters, and enzymes at 10 µM. Cofrogliptin (10 mg/kg) decreases blood glucose levels, increases serum insulin levels, and inhibits serum DPP-4 activity in an oral glucose tolerance test using db/db mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gou, X., Dou, C., Tang, P., et al. Preclinical pharmacological profiles of cofrogliptin, a novel and bi-weekly DPP-4 inhibitor. Front. Pharmacol. 16, 1702101 (2026).