A peptide fragment of thymosin β4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TB-500 (acetate)

Item No. 45081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-threonyl-L-glutamine, acetate
Synonyms
  • Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH
Molecular Formula
C38H68N10O14 • XC2H4O2
Formula Weight
889.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-LKKTETQ-OH
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
CC(O)=O.NC(CC[C@@H](C(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C38H68N10O14.C2H4O2/c1-19(2)18-27(42-22(5)51)35(58)44-23(10-6-8-16-39)32(55)43-24(11-7-9-17-40)33(56)47-30(20(3)49)36(59)45-25(13-15-29(53)54)34(57)48-31(21(4)50)37(60)46-26(38(61)62)12-14-28(41)52;1-2(3)4/h19-21,23-27,30-31,49-50H,6-18,39-40H2,1-5H3,(H2,41,52)(H,42,51)(H,43,55)(H,44,58)(H,45,59)(H,46,60)(H,47,56)(H,48,57)(H,53,54)(H,61,62);1H3,(H,3,4)/t20-,21-,23+,24+,25+,26+,27+,30+,31+;/m1./s1
InChi Key
QQPHIKZJJGWYIR-PFWNPZQHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $65

    Add

    10 mg

    $98

    Add

    25 mg

    $195

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    TB-500 (acetate) is a peptide fragment corresponding to amino acid residues 17-23 of thymosin β4 (Tβ4; Item No. 28605), an actin-sequestering peptide.1 TB-500 inhibits proliferation and migration of PDGF-BB-stimulated hepatic stellate cells at a concentration of 10 ng/ml. Topical application of TB-500 (15 µg/30 µl) reduces wound closure and healing times of skin wounds in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shah, R., Reyes-Gordillo, K., and Rojkind, M. Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain. Expert Opin. Biol. Ther. 18(sup1), 177-184 (2018).

    2. Huang, C.M., Wang, C.C., Barnes, S., et al. In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics 6(21), 5805-5814 (2006).