A cardiotonic agent
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Sulmazole (hydrochloride)

Item No. 45128

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-methoxy-4-(methylsulfinyl)phenyl]-3H-Imidazo[4,5-b]pyridine, monohydrochloride
CAS Number
53930-42-0
Synonyms
  • AR-L 115BS
  • Sumazol
Molecular Formula
C14H13N3O2S • HCl
Formula Weight
323.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CS(C1=CC(OC)=C(C=C1)C2=NC3=NC=CC=C3N2)=O.Cl
InChi Code
InChI=1S/C14H13N3O2S.ClH/c1-19-12-8-9(20(2)18)5-6-10(12)13-16-11-4-3-7-15-14(11)17-13;/h3-8H,1-2H3,(H,15,16,17);1H
InChi Key
BPBGMZMGLZCRCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $124

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    25 mg

    $293

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    50 mg

    $553

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    Product Description

    Sulmazole is a cardiotonic agent.1,2 It increases cAMP accumulation via antagonism of the adenosine A1 receptor (IC50 = 78.1 µM), inhibition of phosphodiesterase (PDE), and reduction of Gi-mediated inhibition of adenylate cyclase in rat adipocyte membranes.1 Sulmazole also selectively inhibits PDE5 over PDE3 (IC50s = 21 and 150 µM, respectively) in a cell-free assay.2 It restores cardiac output, the force of right ventricular contraction, and heart rate, and decreases right atrial pressure in a dog heart-lung preparation model of pentobarbital-induced depressed cardiac function.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parsons, W.J., Ramkumar, V., and Stiles, G.L. The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol. Pharmacol. 33(4), 441-448 (1988).

    2. Coates, W.J., Connolly, B., Dhanak, D., et al. Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: Analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase. J. Med. Chem. 36(10), 1387-1392 (1993).

    3. Morita, T., Satoh, K., and Taira, N. Improvement of cardiac performance by AR-L 115 BS, a new cardiotonic drug, in the experimental failing dog heart. Jpn. Heart J. 25(3), 439-445 (1984).