A multi-kinase inhibitor and derivative of sunitinib
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N,N-dimethyl Sunitinib

Item No. 45148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(dimethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number
326914-17-4
Synonyms
  • SU 11657
Molecular Formula
C20H23FN4O2
Formula Weight
370.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(C)C)=O)=C(N3)C)C)NC1=CC=C2F
InChi Code
InChI=1S/C20H23FN4O2/c1-11-17(23-12(2)18(11)20(27)22-7-8-25(3)4)10-15-14-9-13(21)5-6-16(14)24-19(15)26/h5-6,9-10,23H,7-8H2,1-4H3,(H,22,27)(H,24,26)/b15-10-
InChi Key
MBTDIENWIYANIG-GDNBJRDFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    N,N-dimethyl Sunitinib is a multi-kinase inhibitor and derivative of sunitinib (Item No. 13159).1 It inhibits VEGFR1, VEGFR2, PDGFR, and c-Kit (IC50s = 0.013, 0.017, 0.005, and 0.04 µM, respectively). Oral administration of N,N-dimethyl sunitinib (40 mg/kg) reduces the degradation of cartilage proteoglycan and the severity of arthritis in the K/BxN mouse model of rheumatoid arthritis. N,N-dimethyl Sunitinib also reduces intratumoral angiogenesis and tumor growth in SK-N-AS, MYCN-amplified IMR-32, and SH-SY5Y neuroblastoma mouse xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. De Bandt, M., Ben Mahdi, M.H., Ollivier, V., et al. Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis. J. Immunol. 171(9), 4853-4859 (2003).

    2. Bäckman, U., and Christofferson, R. The selective class III/V receptor tyrosine kinase inhibitor SU11657 inhibits tumor growth and angiogenesis in experimental neuroblastomas grown in mice. Pediatr. Res. 57(5 Pt 1), 690-695 (2005).