A rubber vulcanization accelerator
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DPG

Item No. 45195

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-diphenyl-guanidine
CAS Number
102-06-7
Synonyms
  • 1,3-Diphenylguanidine
  • NSC 3272
Molecular Formula
C13H13N3
Formula Weight
211.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
N=C(NC1=CC=CC=C1)NC2=CC=CC=C2
InChi Code
InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
InChi Key
OWRCNXZUPFZXOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 g

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    500 g

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    Cayman Chemical
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    Product Description

    DPG is a rubber vulcanization accelerator.1 It is cytotoxic to A549 and HepG2 cells (EC50s = 59.4 and 47.7 µM, respectively).2 DPG (10 µg/ml) decreases body length and induces cardiac abnormalities in zebrafish larvae.1 It is associated with allergic contact dermatitis.3 DPG has been found as a contaminant in soil and urban water.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Q., Tang, J., Zhao, S., et al. Assessment of developmental toxicity of 1,3-diphenylguanidine and its chlorinated derivative in zebrafish embryos. Environ. Technol. Innov. 40, (2025).

    2. Marques Dos Santos, M., Cheriaux, C., Jia, S., et al. Genotoxic effects of chlorinated disinfection by-products of 1,3-diphenylguanidine (DPG): Cell-based in-vitro testing and formation potential during water disinfection. J. Hazard Mater. 436, 129114 (2022).

    3. Dejonckheere, G., Herman, A., and Baeck, M. Allergic contact dermatitis caused by synthetic rubber gloves in healthcare workers: Sensitization to 1,3-diphenylguanidine is common. Contact Dermatitis 81(3), 167-173 (2019).

    4. Li, Z.M., Pal, V.K., Kannan, P., et al. 1,3-Diphenylguanidine, benzothiazole, benzotriazole, and their derivatives in soils collected from northeastern United States. Sci. Total Environ. 887, 164110 (2023).

    5. Zhang, H.-Y., Huang, Z., Liu, Y.-H., et al. Occurrence and risks of 23 tire additives and their transformation products in an urban water system. Environ. Int. 171, 107715 (2023).