A selective estrogen receptor modulator
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Methylpiperidino pyrazole (hydrochloride)

Item No. 45218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-[2-(1-piperidinyl)ethoxy]phenyl]-1H-pyrazol-3-yl]-phenol, monohydrochloride
CAS Number
2863676-89-3
Synonyms
  • MPP
Molecular Formula
C29H31N3O3 • HCl
Formula Weight
506.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=C(C(C=C2)=CC=C2OCCN3CCCCC3)N(C(C=C4)=CC=C4O)N=C1C(C=C5)=CC=C5O.Cl
InChi Code
InChI=1S/C29H31N3O3.ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;/h5-16,33-34H,2-4,17-20H2,1H3;1H
InChi Key
NUFZYMONJXOTFN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    Methylpiperidino pyrazole is a selective estrogen receptor modulator (SERM).1,2 It is an estrogen receptor α (ERα) antagonist (Ki = 2.7 nM) and is selective for ERα over ERβ (Ki = 1,800 nM).1 Methylpiperidino pyrazole (1 nM) induces apoptosis in RL-95 endometrial cancer cells.2 In vivo, Methylpiperidino pyrazole (25, 50, and 100 µg/animal) increases uterine weight in ovariectomized mice, indicating differential in vitro versus in vivo endometrial responses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, J., Huang, Y.R., Harrington, W.R., et al. Antagonists selective for estrogen receptor α. Endocrinology 143(3), 941-947 (2002).

    2. Davis, A.M., Ellersieck, M.R., Grimm, K.M., et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol. Reprod. Dev. 73(8), 1034-1044 (2006).