A PEGylated and clickable form of DSPE
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DSPE-PEG(2000)-tetrazine

Item No. 45240

Product Insert (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]ω-[2-[[2-[4-(1,2,4,5-tetrazin-3-yl)phenyl]acetyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl)
CAS Number
3101670-39-4
Synonyms
  • DSPE-PEG(2000)-Tz
Molecular Formula
(C2H4O)nC54H93N6O11P
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly Soluble: 1-10 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOCCNC(CC1=CC=C(C2=NN=CN=N2)C=C1)=O)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $297

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    10 mg

    $495

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    Cayman Chemical
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    Product Description

    DSPE-PEG(2000)-tetrazine is a PEGylated and clickable form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of small molecules in vitro and in vivo.1 LNPs containing DSPE-PEG(2000)-tetrazine and encapsulating SN-38 (Item No. 15632) decrease the viability of HER2-overexpressing NIH3T6.7 cells pre-incubated with trans-cyclooctene-conjugated trastuzumab.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoo, J., Choi, S., Son, J., et al. Click chemistry-mediated tumor-targeting of SN38-loaded nanoparticles using trastuzumab. Biochem. Biophys. Res. Commun. 515(1), 207-213 (2019).