An NLRP3 inflammasome inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Usnoflast

Item No. 45301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2R)-1E,2-dimethyl-2-pyrrolidinyl]-N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-ethenesulfonamide
CAS Number
2455519-86-3
Synonyms
  • ZYIL1
Molecular Formula
C21H29N3O3S
Formula Weight
403.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
C[C@]1(N(CCC1)C)/C=C/S(NC(NC2=C3C(CCC3)=CC4=C2CCC4)=O)(=O)=O
InChi Code
InChI=1S/C21H29N3O3S/c1-21(10-5-12-24(21)2)11-13-28(26,27)23-20(25)22-19-17-8-3-6-15(17)14-16-7-4-9-18(16)19/h11,13-14H,3-10,12H2,1-2H3,(H2,22,23,25)/b13-11+/t21-/m1/s1
InChi Key
HAMGPBKPACGWND-ZOXUKVPXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $449

    Add

    5 mg

    $1,123

    Add

    10 mg

    $1,796

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Usnoflast is an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome.1 It inhibits oligomerization of apoptosis-associated speck-like protein (ASC), a component of the NLRP3 inflammasome complex, in LPS-primed and ATP-activated THP-1 cells. Usnoflast reduces IL-1β release induced by nigericin (Item No. 11437) in LPS-primed THP-1 cells and microglia (IC50s = 11 and 43 nM, respectively). It also reduces ATP-induced IL-1β release in LPS-primed human peripheral blood mononuclear cells (PBMCs; IC50 = 4.5 nM). Usnoflast (30 mg/kg) improves motor function and reduces brain α-synuclein levels in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chatterjee, A., Mohapatra, J., Sharma, M., et al. A novel selective NLRP3 inhibitor shows disease-modifying potential in animal models of Parkinson’s disease. Brain Res. 1842, 149129 (2024).