An AAK1 inhibitor
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BMS 911172

Item No. 45308

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-amino-N-[3-(difluoromethoxy)-4-(5-oxazolyl)phenyl]-4-methyl-pentanamide
CAS Number
1644248-18-9
Molecular Formula
C16H19F2N3O3
Formula Weight
339.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
FC(F)OC1=C(C2=CN=CO2)C=CC(NC([C@H](N)CC(C)C)=O)=C1
InChi Code
InChI=1S/C16H19F2N3O3/c1-9(2)5-12(19)15(22)21-10-3-4-11(14-7-20-8-23-14)13(6-10)24-16(17)18/h3-4,6-9,12,16H,5,19H2,1-2H3,(H,21,22)/t12-/m1/s1
InChi Key
GCTFTMWXZFLTRR-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $175

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    10 mg

    $298

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    25 mg

    $481

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    50 mg

    $700

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    Product Description

    BMS 911172 is an AP2-associated kinase 1 (AAK1) inhibitor that reduces the phosphorylation of AP-2 complex subunit mu2 (AP2M2) in HEK293 cells overexpressing AAK1 and AP2M2 (IC50 = 0.051 µM).1 It is selective for AAK1 over a panel of 219 kinases, including BMP2-inducible kinase (BIKE), cyclin G-associated kinase (GAK), and serine/threonine kinase 16 (STK16; IC50s = 0.120, 1.06, and 15.8 µM, respectively). BMS 911172 also inhibits AP2M2 phosphorylation in mouse brain lysates (ED50 = 6 mg/kg). In vivo, BMS 911172 (30 mg/kg) reduces formalin-induced paw flinching and biting in a rat model of persistent pain. It also reduces thermal and mechanical hyperalgesia, as well as cold and mechanical allodynia, in a rat model of chronic constriction injury when administered at a dose of 60 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Havey, L., You, H., Asara, J.M., et al. Epstein-barr virus-driven B-cell transformation under germinal center hypoxia requires external unsaturated fatty acids. Res. Sq. Rs. 3, RS6506954 (2025).