A pan-JNK inhibitor
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SR 3306

Item No. 45342

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[3-(6-methyl-3-pyridinyl)-1H-1,2,4-triazol-1-yl]phenyl]-4-[3-(4-morpholinyl)phenyl]-2-pyrimidinamine
CAS Number
1128096-91-2
Molecular Formula
C28H26N8O
Formula Weight
490.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CC1=CC=C(C=N1)C(N=C2)=NN2C(C=C3)=CC=C3NC4=NC=CC(C5=CC(N6CCOCC6)=CC=C5)=N4
InChi Code
InChI=1S/C28H26N8O/c1-20-5-6-22(18-30-20)27-31-19-36(34-27)24-9-7-23(8-10-24)32-28-29-12-11-26(33-28)21-3-2-4-25(17-21)35-13-15-37-16-14-35/h2-12,17-19H,13-16H2,1H3,(H,29,32,33)
InChi Key
QDMXVKKPYBGIAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    SR 3306 is a pan-JNK inhibitor (IC50s = 67, 283, and 159 nM for JNK1, JNK2, and JNK3, respectively).1 It is selective for JNK1-3 over p38 MAPK (IC50 = >20 µM). SR 3306 (300-1,000 nM) reduces cell death induced by N-methyl-4-phenylpyridinium (MPP+) in primary rat mesencephalic dopaminergic neurons. It reduces MPTP- or 6-OHDA-induced neurodegeneration of dopaminergic neurons in the mouse substantia nigra pars compacta.1,2 SR 3306 (10 mg/kg) decreases D-amphetamine-induced circling in rats in a 6-OHDA model of Parkinson’s disease.2 It also enhances leptin-induced STAT3 activation in the hypothalamus, reduces food intake, decreases body weight in diet-induced obese (DIO) mice when administered at a dose of 30 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chambers, J.W., Pachori, A., Howard, S., et al. Small molecule c-jun-N-terminal kinase (JNK) inhibitors protect dopaminergic neurons in a model of Parkinson’s disease. ACS Chem. Neurosci. 2(4), 198-206 (2011).

    2. Crocker, C.E., Khan, S., Cameron, M.D., et al. JNK Inhibition protects dopamine neurons and provides behavioral improvement in a rat 6-hydroxydopamine model of Parkinson’s disease. ACS Chem. Neurosci. 2(4), 207-212 (2011).

    3. Gao, S., Howard, S., and LoGrasso, P.V. Pharmacological inhibition of c-Jun N-terminal kinase reduces food intake and sensitizes leptin’s anorectic signaling actions. Sci. Rep. 7, 41795 (2017).