A dual inhibitor of FLT3D835Y and FAK
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FLT3-IN-17

Item No. 45396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[2-[[4-(1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]-methanesulfonamide
CAS Number
2758999-62-9
Molecular Formula
C23H24N6O2S2
Formula Weight
480.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CS(NC1=CC=CC(C2=CSC3=C2N=C(N=C3)NC(C=C4)=CC=C4N5CCNCC5)=C1)(=O)=O
InChi Code
InChI=1S/C23H24N6O2S2/c1-33(30,31)28-18-4-2-3-16(13-18)20-15-32-21-14-25-23(27-22(20)21)26-17-5-7-19(8-6-17)29-11-9-24-10-12-29/h2-8,13-15,24,28H,9-12H2,1H3,(H,25,26,27)
InChi Key
MGKRFMQUFDKUBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $293

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    10 mg

    $483

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    25 mg

    $949

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    Product Description

    FLT3-IN-17 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) expressing a D835Y mutation associated with quizartinib resistance and focal adhesion kinase (FAK; IC50s = <0.5 and 12 nM in cell-free assays).1 It inhibits the growth of HCT116 colorectal cancer cells, MDA-MB-231 breast cancer cells, and A375 human melanoma cells (GI50s = 0.25, 0.46, and 0.49 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, H., Shin, I., Yoon, H., et al. Identification of thieno[3,2-d]pyrimidine derivatives as dual inhibitors of focal adhesion kinase and FMS-like tyrosine kinase 3. J. Med. Chem. 64(16), 11934-11957 (2021).