A UBE2T inhibitor
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M435-1279

Item No. 45401

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(aminosulfonyl)phenyl]-1,2,5,6,7,8-hexahydro-4-hydroxy-2-oxo-[1]benzothieno[2,3-b]pyridine-3-carboxamide
CAS Number
1359431-16-5
Molecular Formula
C18H17N3O5S2
Formula Weight
419.5
Purity
≥98%
Formulation (Request formulation change)
a solid
SMILES
O=C(C1=C(O)C2=C(SC3=C2CCCC3)NC1=O)NC4=CC=C(S(=O)(N)=O)C=C4
InChi Code
InChI=1S/C18H17N3O5S2/c19-28(25,26)10-7-5-9(6-8-10)20-16(23)14-15(22)13-11-3-1-2-4-12(11)27-18(13)21-17(14)24/h5-8H,1-4H2,(H,20,23)(H2,19,25,26)(H2,21,22,24)
InChi Key
MVQJFYRZMPKNIV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $135

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    10 mg

    $221

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    25 mg

    $429

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    Cayman Chemical
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    Product Description

    M435-1279 is an inhibitor of ubiquitin-conjugating enzyme E2T (UBE2T).1 It binds to UBE2T (Kd = 50.5 µM), inhibits UBE2T-mediated degradation of receptor for activated C kinase 1 (RACK1), and reduces hyperactive Wnt/β-catenin signaling. M435-1279 reduces the viability of MKN45 and AGS gastric cancer cells when used at concentrations ranging from 4 to 32 µM. Intratumoral administration of M435-1279 (5 mg/kg per day) reduces tumor growth in an MKN45 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, Z., Jiang, X., Qin, L., et al. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination. Oncogene 40(5), 1027-1042 (2021).