An ionizable cationic lipid
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FS01

Item No. 45431

Product Insert (PDF)
Technical Information
Formal Name
2-butylphenethyl 8-((8-(heptadecan-9-yloxy)-8-oxooctyl)(3-((2-(methylamino)-3,4-dioxocyclobut-1-en-1-yl)amino)propyl)amino)octanoate
Molecular Formula
C53H91N3O6
Formula Weight
866.3
Purity
≥98%
Formulation
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥ 10 mg/ml
SMILES
CCCCCCCCC(CCCCCCCC)OC(CCCCCCCN(CCCCCCCC(OCCC1=C(CCCC)C=CC=C1)=O)CCCNC(C2=O)=C(NC)C2=O)=O
InChi Code
InChI=1S/C53H91N3O6/c1-5-8-11-13-17-23-35-47(36-24-18-14-12-9-6-2)62-49(58)38-26-20-16-22-30-42-56(43-31-40-55-51-50(54-4)52(59)53(51)60)41-29-21-15-19-25-37-48(57)61-44-39-46-34-28-27-33-45(46)32-10-7-3/h27-28,33-34,47,54-55H,5-26,29-32,35-44H2,1-4H3
InChi Key
JGXIAHAYAXEUMA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $212

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    10 mg

    $382

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    25 mg

    $848

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    50 mg

    $1,378

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    Cayman Chemical
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    Product Description

    FS01 is an ionizable cationic lipid (pKa = 6.45) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 FS01 increases the stability of mRNA, and LNPs containing FS01 have an encapsulation efficiency of >97% and a particle size smaller than that of LNPs containing SM-102 (Item No. 33474), DLin-MC3-DMA (Item No. 34364), or ALC-0315 (Item No. 34337). LNPs containing FS01 and encapsulating varicella-zoster virus (VZV) glycoprotein E mRNA elicit greater glycoprotein E IgG and T cell responses than DLin-MC3-DMA-containing LNPs in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, K., Bu, L., Du, J., et al. A novel ionizable lipid with comprehensive improvements in transfection potency, immune profile and safety of lipid nanoparticle. J. Control Release 386:114126, (2025).