An inhibitor of VEGFR2
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

VEGFR2 Kinase Inhibitor IV

Item No. 45474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-methoxyphenyl)-3-(3-thienyl)-pyrazolo[1,5-a]pyrimidine
CAS Number
216661-57-3
Synonyms
  • Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor IV
Molecular Formula
C17H13N3OS
Formula Weight
307.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlMethanol:Chloroform (1:1): Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC=C(C=C1)C2=CN3N=CC(C4=CSC=C4)=C3N=C2
InChi Code
InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3
InChi Key
HBWLNACPIFKNIP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $199

    Add

    5 mg

    $749

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    VEGFR2 kinase inhibitor IV is an inhibitor of VEGFR2 (IC50 = 19 nM).1 It is greater than 100-fold selective for VEGFR2 over FGFR1 and Src but only 1.8-, 10-, and 10-fold selective over PDGFRβ, FLT1, and FLT2, respectively. VEGFR2 kinase inhibitor IV inhibits mitogenesis in human umbilical vein endothelial cells (HUVECs; IC50 = 387 nM). It also reduces VEGF-induced increases in neuroglobin levels in primary mouse cerebrocortical neurons when used at a concentration of 20 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fraley, M.E., Hoffman, W.F., Rubino, R.S., et al. Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: A new class of KDR kinase inhibitors. Bioorg. Med. Chem. Lett. 12(19), 2767-2770 (2002).

    2. Jin, K., Mao, X., Xie, L., et al. Interactions between vascular endothelial growth factor and neuroglobin. Neurosci. Lett. 519(1), 47-50 (2012).