A LCK inhibitor
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LCK Inhibitor II

Item No. 45496

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[2-(1H-benzimidazol-1-yl)-6-[2-(4-morpholinyl)ethoxy]-4-pyrimidinyl]amino]-4-methyl-phenol
CAS Number
918870-43-6
Synonyms
  • Lymphocyte-specific Protein Tyrosine Kinase II
Molecular Formula
C24H26N6O3
Formula Weight
446.5
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
OC1=CC=C(C)C(NC2=NC(N3C4=C(N=C3)C=CC=C4)=NC(OCCN5CCOCC5)=C2)=C1
InChi Code
InChI=1S/C24H26N6O3/c1-17-6-7-18(31)14-20(17)26-22-15-23(33-13-10-29-8-11-32-12-9-29)28-24(27-22)30-16-25-19-4-2-3-5-21(19)30/h2-7,14-16,31H,8-13H2,1H3,(H,26,27,28)
InChi Key
DKDNLOIZODSWFH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $446

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    Product Description

    LCK inhibitor II is an inhibitor of LCK (IC50 = 3 nM in a cell-free assay).1 It reduces IL-2 levels in Jurkat cells (IC50 = 54 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sabat, M., VanRens, J.C., Laufersweiler, M.J., et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Biooorg. Med. Chem. Lett. 16(23), 5973-5977 (2006).