A more reactive form of DSPE-PEG(2000)-TCO
Related Products
Alternative(s)
43626DSPE-PEG(2000)-TCO
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DSPE-PEG(2000)-TCO (axial)

Item No. 45526

Product Insert (PDF)
Technical Information
Formal Name
(2R)-3-((((1-(((R,E)-cyclooct-4-en-1-yl)oxy)-1,9-dioxo-5,8-dioxa-2,10-diazadodecan-12-yl)oxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl distearate
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-trans-cyclooctene (axial)
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-2000-trans-cyclooctene (axial)
Molecular Formula
(C2H4O)nC53H99N2O12P
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(O[C@H]1CC/C([H])=C([H])/CCC1)NCCOCCOC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $195

    Add

    10 mg

    $371

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    DSPE-PEG(2000)-TCO (axial) is a more reactive form of DSPE-PEG(2000)-TCO in which the TCO moiety is in the axial conformation, which increases its reactivity.1 DSPE-PEG(2000)-TCO (axial) can be used for bioorthogonal ligation of lipid nanoparticles (LNPs).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pigga, J.E., Rosenberger, J.E., Jemas, A., et al. General, divergent platform for diastereoselective synthesis of trans-cyclooctenes with high reactivity and favorable physiochemical properties. Angew. Chem. Int. Ed. Engl. 60(27), 14975-14980 (2021).

    2. Marqués-Gallego, P., and de Kroon, A.I. Ligation strategies for targeting liposomal nanocarriers. Biomed. Res. Int. 129458 (2014).