An endogenous peptide and NTS receptor ligand
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Xenin-25 (acetate)

Item No. 45528

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine, acetate
Synonyms
  • Xenopsin-25
Molecular Formula
C139H224N38O32S • XC2H4O2
Formula Weight
2971.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
H-MLTKFETLSARVKGLSFHPKRPWIL-OH
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@H](C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CCCCN[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](O[H])C)([H])C(N[C@@H](CCCCN[H])C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(NCC(N[C@H](C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CC1=CN([H])C=N1)C(N2CCC[C@H]2C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N3CCC[C@H]3C(N[C@@H](CC4=CN([H])C5=C4C=CC=C5)C(N[C@@](C(N[C@H](C(O)=O)CC(C)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)CC(C)C)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)CC(C)C)[C@H](CCSC)N[H].CC(O)=O
InChi Code
InChI=1S/C139H224N38O32S.C2H4O2/c1-15-79(10)111(132(203)169-103(137(208)209)64-77(6)7)173-126(197)101(67-85-69-152-89-41-23-22-40-87(85)89)167-130(201)107-49-34-59-176(107)135(206)96(47-33-58-151-139(147)148)163-117(188)91(43-25-29-54-141)159-129(200)106-48-35-60-177(106)136(207)102(68-86-70-149-74-154-86)168-124(195)100(66-84-38-20-17-21-39-84)166-128(199)105(73-179)171-122(193)97(62-75(2)3)156-108(182)71-153-116(187)90(42-24-28-53-140)160-131(202)110(78(8)9)172-120(191)94(46-32-57-150-138(145)146)157-114(185)80(11)155-127(198)104(72-178)170-119(190)93(45-27-31-56-143)162-133(204)112(81(12)180)174-121(192)95(50-51-109(183)184)158-123(194)99(65-83-36-18-16-19-37-83)165-118(189)92(44-26-30-55-142)161-134(205)113(82(13)181)175-125(196)98(63-76(4)5)164-115(186)88(144)52-61-210-14;1-2(3)4/h16-23,36-41,69-70,74-82,88,90-107,110-113,152,178-181H,15,24-35,42-68,71-73,140-144H2,1-14H3,(H,149,154)(H,153,187)(H,155,198)(H,156,182)(H,157,185)(H,158,194)(H,159,200)(H,160,202)(H,161,205)(H,162,204)(H,163,188)(H,164,186)(H,165,189)(H,166,199)(H,167,201)(H,168,195)(H,169,203)(H,170,190)(H,171,193)(H,172,191)(H,173,197)(H,174,192)(H,175,196)(H,183,184)(H,208,209)(H4,145,146,150)(H4,147,148,151);1H3,(H,3,4)/t79-,80-,81+,82+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,110-,111-,112-,113-;/m0./s1
InChi Key
RZITYMYGJDRACU-OQVOPOPSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Xenin-25 is an endogenous peptide and a neurotensin (NTS) receptor ligand.1 It binds to NTS receptors in HEK293 cell membranes expressing the mouse receptor. It is expressed in K cells in the small intestine and co-secreted with glucose-dependent insulinotropic polypeptide (GIP).2 Xenin-25 (1 µM) stimulates the release of insulin in BRIN-BD11 rat pancreatic β-cells in the presence of glucose and increases the insulinotropic response of glucagon-like peptide 1 (GLP-1), GIP, and neurotensin in the same cells.2 It prevents increases in plasma glucose levels in mice when administered 30 minutes before a subcutaneous injection of glucose. Xenin-25 inhibits gastric acid release stimulated by pentagastrin (Item No. 28546), increases pancreatic protein secretion, and stimulates contraction of the jejunum in anesthetized dogs.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Botto, J.M., Chabry, J., Sarret, P., et al. Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: Binding properties, photoaffinity labeling, and internalization mechanism. Biochem. Biophys. Res. Commun. 243(2), 585-590 (1998).

    2. Taylor, A.I., Irwin, N., McKillop, A.M., et al. Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. J. Endocrinol. 207(1), 87-93 (2010).

    3. Feurle, G.E., Heger, M., Niebergall-Roth, E., et al. Gastroenteropancreatic effects of xenin in the dog. J. Pept. Res. 49(4), 324-330 (1997).