An immunogenic T cell epitope
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Insulin Peptide (sodium salt)

Item No. 45530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-histidyl-L-leucyl-L-valyl-L-α-glutamyl-L-alanyl-L leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinylglycyl-L-α-glutamyl-L-arginyl-glycine, sodium salt
Synonyms
  • InsB9-23
  • Insulin B: 9-23
  • Insulin B Chain (9-23)
  • Preproinsulin (33-47) (human, mouse, rat, porcine, bovine, ovine)
Molecular Formula
C72H116N20O22S • XNa
Formula Weight
1645.9
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
SHLVEALYLVCGERG-OH
Solubility(Learn about Variance in Solubility)
Methanol:Chloroform (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H](CC1=CN([H])C=N1)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CS[H])C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)C)=O)=O)=O)CC(C)C)=O)[C@H](CO[H])N[H]
InChi Code
InChI=1S/C72H116N20O22S/c1-34(2)23-47(85-59(102)39(11)81-63(106)46(19-21-55(98)99)84-70(113)57(37(7)8)91-69(112)49(25-36(5)6)88-67(110)51(27-41-28-76-33-80-41)86-60(103)43(73)31-93)65(108)89-50(26-40-14-16-42(94)17-15-40)66(109)87-48(24-35(3)4)68(111)92-58(38(9)10)71(114)90-52(32-115)62(105)78-29-53(95)82-45(18-20-54(96)97)64(107)83-44(13-12-22-77-72(74)75)61(104)79-30-56(100)101/h14-17,28,33-39,43-52,57-58,93-94,115H,12-13,18-27,29-32,73H2,1-11H3,(H,76,80)(H,78,105)(H,79,104)(H,81,106)(H,82,95)(H,83,107)(H,84,113)(H,85,102)(H,86,103)(H,87,109)(H,88,110)(H,89,108)(H,90,114)(H,91,112)(H,92,111)(H,96,97)(H,98,99)(H,100,101)(H4,74,75,77)/t39-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-/m0/s1
InChi Key
KGWWUFWQLUNEAA-WEYRIZTLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Insulin peptide is a dominant immunogenic T cell epitope involved in the pathogenesis of type 1 diabetes.1,2 It binds to HLA-DQ8 and I-Ag7 from non-obese diabetic (NOD) mice.1 Insulin peptide induces proliferation in a lymph node proliferation assay using lymph node cells isolated from NOD mice immunized with insulin peptide.2 Subcutaneous or intranasal administration of insulin peptide with incomplete Freund's adjuvant decreases the incidence of diabetes in NOD mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, K.H., Wucherpfennig, K.W., and Wiley, D.C. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2(6), 501-507 (2001).

    2. Daniel, D., and Wegmann, D.R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. U.S.A. 93(2), 956-960 (1996).