A peptide fragment of insulin with a C19S single amino acid variant
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Insulin Peptide (C19S) (trifluoroacetate salt)

Item No. 45531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-histidyl-L-leucyl-L-valyl-L-α-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-serylglycyl-L-α-glutamyl-L-arginyl-glycine, trifluoroacetate salt
Synonyms
  • InsB9-23(C19S)
  • [19Ser] Insulin Peptide
Molecular Formula
C72H116N20O23 • XCF3COOH
Formula Weight
1629.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
SHLVEALYLVSGERG-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (7.2 pH): Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H](CC1=CN([H])C=N1)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO[H])C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)CC(C)C)=O)C)=O)=O)=O)CC(C)C)=O)[C@H](CO[H])N[H].O=C(O)C(F)(F)F
InChi Code
InChI=1S/C72H116N20O23.C2HF3O2/c1-34(2)23-47(85-59(103)39(11)81-63(107)46(19-21-55(99)100)84-70(114)57(37(7)8)91-69(113)49(25-36(5)6)88-67(111)51(27-41-28-76-33-80-41)86-60(104)43(73)31-93)65(109)89-50(26-40-14-16-42(95)17-15-40)66(110)87-48(24-35(3)4)68(112)92-58(38(9)10)71(115)90-52(32-94)62(106)78-29-53(96)82-45(18-20-54(97)98)64(108)83-44(13-12-22-77-72(74)75)61(105)79-30-56(101)102;3-2(4,5)1(6)7/h14-17,28,33-39,43-52,57-58,93-95H,12-13,18-27,29-32,73H2,1-11H3,(H,76,80)(H,78,106)(H,79,105)(H,81,107)(H,82,96)(H,83,108)(H,84,114)(H,85,103)(H,86,104)(H,87,110)(H,88,111)(H,89,109)(H,90,115)(H,91,113)(H,92,112)(H,97,98)(H,99,100)(H,101,102)(H4,74,75,77);(H,6,7)/t39-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-;/m0./s1
InChi Key
WXZYMTRDIYBSPY-PEIUHMAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Insulin peptide (C19S) is a peptide fragment of insulin with a single amino acid variant (SAV) of cysteine-to-serine at position 19 that corresponds to residues 32-57 of full-length insulin.1 It is formed post-translationally via a process driven by oxidative stress in the islet microenvironment. Insulin peptide (C19S) has been identified in the islet I-Ag7 peptidome of non-obese diabetic (NOD) mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Srivastava, N., Vomund, A.N., Yu, R., et al. A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes. BioRxiv 15, 622538 (2025).