Bisphenol F

Bisphenol F (BPF) is a derivative of bisphenol A (BPA), an environmental contaminant, and an endocrine disruptor.^1,2,3 It has been detected in personal care products, wastewater treatment sludge, bottled water, and canned foods.^2,3,4 BPF has estrogenic activity in vitro and in female rats.² It also has neurotoxic effects, affecting neural stem cell proliferation and differentiation, synapse formation, and cell viability in vitro and in animal models, as well as CNS morphology, locomotion, and cognition in animal models.¹ BPF increases hepatic triglyceride and fatty acid levels in mice, and serum levels of BPF are increased in patients with non-alcoholic fatty liver disease (NAFLD).⁵

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1. Cantua, R., and Mulligan, K. Developmental neurotoxicity of bisphenol F and bisphenol S in animal model systems: A literature review. Neurotoxicology 108, 263-280 (2025).

2. Rochester, J.R., and Bolden, A.L. Bisphenol S and F: A systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ. Health Perspect. 123(7), 643-650 (2015).

3. Lee, S., Liao, C., Song, G.J., et al. Emission of bisphenol analogues including bisphenol A and bisphenol F from wastewater treatment plants in Korea. Chemosphere 119, 1000-1006 (2015).

4. Zhou, J., Chen, X.H., Pan, S.D., et al. Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province. Food Chem. 294, 160-170 (2019).

5. Wang, J., Yu, P., Xie, X., et al. Bisphenol F induces nonalcoholic fatty liver disease-like changes: Involvement of lysosome disorder in lipid droplet deposition. Environ. Pollut. 271, 116304 (2021).