A bumped kinase inhibitor
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3BrB-PP1

Item No. 45582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(3-bromophenyl)methyl]1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
956025-99-3
Molecular Formula
C16H18BrN5
Formula Weight
360.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC(C)(N1C2=C(C(N)=NC=N2)C(CC3=CC(Br)=CC=C3)=N1)C
InChi Code
InChI=1S/C16H18BrN5/c1-16(2,3)22-15-13(14(18)19-9-20-15)12(21-22)8-10-5-4-6-11(17)7-10/h4-7,9H,8H2,1-3H3,(H2,18,19,20)
InChi Key
FTICVONBLRGQJW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $169

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    10 mg

    $321

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    25 mg

    $761

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    50 mg

    $1,437

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    Product Description

    3BrB-PP1 is a bumped kinase inhibitor (BKI) that acts as a selective, ATP-competitive inhibitor of kinases with gatekeeper mutations.1 It increases the activity of the T. gondii bradyzoite-specific BAG1 promoter. 3BrB-PP1 has been used to study kinase activity using kinases containing mutations at gatekeeper residues in the ATP-binding pocket, thereby allowing 3BrB-PP1 to selectively inhibit the kinase.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sugia, T., Masatania, T., Murakoshia, F., et al. Microplate assay for screening Toxoplasma gondii bradyzoite differentiation with DUAL luciferase assay. Anal. Biochem. 464, 9-11 (2014).

    2. Mutavchiev, D.R., Leda, M., and Sawin, K.E. Remodeling of the fission yeast Cdc42 cell-polarity module via the Sty1 p38 stress-activated protein kinase pathway. Curr. Biol. 26(21), 2921-2928 (2016).

    3. Tay, Y.D., Leda, M., Spanos, C., et al. Fission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of the exocyst complex. Cell Rep. 26(6), 1654-1667 (2019).