An inhibitor of USP30
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CMPD-39

Item No. 45608

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-N-[4-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-α-[(4-fluorobenzoyl)amino]-benzenepropanamide
CAS Number
2242582-40-5
Synonyms
  • USP30inh
Molecular Formula
C26H28FN3O4S
Formula Weight
497.6
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@H](CC2=CC=CC=C2)NC(C3=CC=C(F)C=C3)=O)=O)=O
InChi Code
InChI=1S/C26H28FN3O4S/c1-26(2,3)30-35(33,34)22-15-13-21(14-16-22)28-25(32)23(17-18-7-5-4-6-8-18)29-24(31)19-9-11-20(27)12-10-19/h4-16,23,30H,17H2,1-3H3,(H,28,32)(H,29,31)/t23-/m0/s1
InChi Key
NRHPFMQPXSSELC-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $196

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    10 mg

    $368

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    25 mg

    $490

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    Product Description

    CMPD-39 is an inhibitor of ubiquitin-specific protease 30 (USP30; IC50 = 20 nM in a cell-free assay).1 It is selective for USP30 over a panel of 39 other deubiquitinases at 10 µM.2 CMPD-39 increases the number and size of mitolysosomes in SH-SY5Y cells and increases pexophagy in U2OS cells. It restores mitophagy in dopaminergic neurons derived from Parkinson's disease patient-derived induced neuronal progenitor cells that were generated from fibroblasts harboring a loss of function mutation in PRKN.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kluge, A.F., Lagu, B.R., Maiti, P., et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg. Med. Chem. Lett. 28(15), 2655-2659 (2018).

    2. Rusilowicz-Jones, E.V., Barone, F.G., Lopes, F.M., et al. Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. Life Sci. Alliance 5(2), e202101287 (2021).