A tire rubber antioxidant
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TMQ

Item No. 45640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dihydro-2,2,4-trimethyl-quinoline
CAS Number
147-47-7
Synonyms
  • NSC 4175
  • Polnox R
  • 2,2,4-Trimethyl-1,2-dihydroquinoline
Molecular Formula
C12H15N
Formula Weight
173.3
Purity
≥95%
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC(C1=CC=CC=C1N2)=CC2(C)C
InChi Code
InChI=1S/C12H15N/c1-9-8-12(2,3)13-11-7-5-4-6-10(9)11/h4-8,13H,1-3H3
InChi Key
ZNRLMGFXSPUZNR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

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    10 g

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    25 g

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    Cayman Chemical
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    Product Description

    TMQ is a tire rubber antioxidant.1 Topical application of TMQ increases the incidence of renal tubule adenoma and carcinoma in male rats and induces acanthosis and hyperkeratosis of the skin at the application site in male and female rats.2 It has been found in tire and road wear particles (TRWPs) from air and road samples.3,4 Formulations containing TMQ have been used as stabilizing and antioxidant additives in rubber and latex.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shetye, S.S., and Ambare, S.N. Optimisation and evaluation of 2,2,4-trimethyl-1,2-dihydroquinoline (TMQ) and alkyl derivative of P-phenylene diamine (6PPD) and characterisation of rubber valcanisates. Res. J. Chem. Environ. 24(4), 107-117 (2020).

    2. Irwin, R.D., French, J.E., Elwell, M., et al. Carcinogenicity of dermally administered 1,2-dihydro-2,2,4-trimethylquinoline monomer in F344 rats and B6C3F1 mice. J. Appl. Toxicol. 19(2), 125-132 (1999).

    3. Kuntz, V., Zahn, D., and Reemtsma, T. Quantification and occurrence of 39 tire-related chemicals in urban and rural aerosol from Saxony, Germany. Environ. Int. 194:109189, (2024).

    4. Calarnou, L., Traïkia, M., Leremboure, M., et al. Assessing biodegradation of roadway particles via complementary mass spectrometry and NMR analyses. Sci. Total Environ. 900:165698, (2023).