A PTER inhibitor
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PTERi

Item No. 45644

Product Insert (PDF)
Technical Information
Formal Name
3-[2-[2-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)ethoxy]ethoxy]-N-hydroxy-propanamide
CAS Number
3114432-21-9
Synonyms
  • Phosphotriesterase-related Protein Inhibitor
Molecular Formula
C19H20N2O6
Formula Weight
372.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
ONC(CCOCCOCCN(C(C1=CC=CC2=CC=CC3=C12)=O)C3=O)=O
InChi Code
InChI=1S/C19H20N2O6/c22-16(20-25)7-9-26-11-12-27-10-8-21-18(23)14-5-1-3-13-4-2-6-15(17(13)14)19(21)24/h1-6,25H,7-12H2,(H,20,22)
InChi Key
ZVQXBSZUHNRXLS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $199

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    5 mg

    $796

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    10 mg

    $1,194

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PTERi is an inhibitor of phosphotriesterase-related protein (PTER; IC50 = 830 nM for the human enzyme), an aminohydrolase involved in the metabolism of the anorexigenic metabolite N-acetyl taurine (Item No. 35169).1 It is selective for PTER over a panel of 13 histone deacetylases (HDACs) and sirtuins (SIRTs) at 100 µM but does inhibit HDAC8 and HDAC10 by >80% at 100 µM. Acute administration of PTERi (100 mg/kg) increases plasma N-acetyl taurine levels in lean and diet-induced obese (DIO) mice and chronic administration over four weeks decreases food intake and body weight in DIO mice. It also enhances loss of body weight and reductions in food intake induced by semaglutide (Item Nos. 40231 | 29969 | 40170) in DIO mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fu, S., Wang, L., Li, V.L., et al. A small molecule PTER-selective inhibitor reduces food intake and body weight. Cell Chem. Biol. 33(3), 353-363 (2026).