A brain-penetrant ferroptosis inhibitor
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D12

Item No. 45652

Product Insert (PDF)
Technical Information
Formal Name
[1-(acetyloxy)-3-indolizinyl](2-methylphenyl)-methanone
CAS Number
3126217-49-7
Synonyms
  • Ferroptosis-IN-24
Molecular Formula
C18H15NO3
Formula Weight
293.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC(OC1=C(C=CC=C2)N2C(C(C3=C(C)C=CC=C3)=O)=C1)=O
InChi Code
InChI=1S/C18H15NO3/c1-12-7-3-4-8-14(12)18(21)16-11-17(22-13(2)20)15-9-5-6-10-19(15)16/h3-11H,1-2H3
InChi Key
HKCMACVWPBSTPB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $79

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    5 mg

    $316

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    10 mg

    $593

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    Product Description

    D12 is a brain-penetrant ferroptosis inhibitor.1 It inhibits ferroptosis induced by RSL3 (Item No. 19288) in PC12 cells (EC50 = 39.7 nM) by reducing oxidative stress and lipid peroxidation, thereby reducing RSL3-mediated compensatory activation of Nrf2. It also inhibits ferroptosis induced by erastin (Item No. 17754) in PC12 cells (EC50 = 410 nM). Intraperitoneal administration of D12 (10 and 20 mg/kg) restores hepatic glutathione (GSH) and malondialdehyde (MDA) levels and reduces liver injury induced by acetaminophen (Item No. 10024) in a mouse model of acute liver injury. It also reduces infarct volume and neurological deficits in a rat model of cerebral ischemia-reperfusion injury when administered intravenously at 1 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shu, Y., Jiang, Y., Xiong, Y., et al. Design, synthesis, and evaluation of indolizine derivatives as nonclassical ferroptosis inhibitors with efficacy in acute liver injury and ischemic stroke models. J. Med. Chem. 69(7), 8051-8074 (2026).