An internal standard for the quantification of β-sitosterol and γ-sitosterol
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Sitosterol-d7

Item No. 45691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,24ξ)-stigmast-5-en-25,26,26,26,27,27,27-d7-3-ol
CAS Number
2260669-28-9
Molecular Formula
C29H43D7O
Formula Weight
421.8
Purity
≥99% deuterated forms (d1-d7)
Formulation (Request formulation change)
A 1 mg/ml solution in ethyl acetate
SMILES
CCC(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21?,23+,24+,25-,26+,27+,28+,29-/m1/s1/i2D3,3D3,19D
InChi Key
KZJWDPNRJALLNS-GNYYFJBRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Sitosterol-d7 is intended for use as an internal standard for the quantification of β-sitosterol and γ-sitosterol by GC- or LC-MS. Sitosterol-d7 is a mixture of the diastereomers β- and γ-sitosterol that contain seven deuterium atoms. β- and γ-sitosterol are phytosterols found in a variety of plants.1,2 β-sitosterol has diverse activities, including antimicrobial, antioxidant, anticancer, and anti-inflammatory effects, while γ-sitosterol has anticancer activity. β-sitosterol has been used in place of, or in addition to, cholesterol in lipid nanoparticles (LNPs), resulting in improved transfection efficiency and cargo delivery to immune cells.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khan, Z., Nath, N., Rauf, A., et al. Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications. Chem. Biol. Interact. 365, 110117 (2022).

    2. Teodhora., Hendriani, R., Sumiwi, S.A., et al. Peperomia pellucida (L.) Kunth: A decade of ethnopharmacological, phytochemical, and pharmacological insights (2014-2025). J. Exp. Pharmacol. 17, 417-454 (2025).

    3. Han, Y., Wang, Y., Gao, X., et al. Engineering lipid nanoparticles for precision RNA delivery: Design principles, targeting strategies, and clinical prospects. Cancer Nexus 2(2), e70021 (2026).

    4. Chilumula, S., Hanchate, P., Patri, S.V., et al. Influence of structural modifications in synthetic vectors of lipid adjuvants on mRNA vaccine delivery. Biomater. Sci. 13(18), 4952-4969 (2025).