A derivative of pantothenic acid
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Hopantenate (calcium salt)

Item No. 45696

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino-butanoic acid, calcium salt
CAS Number
17097-76-6
Synonyms
  • HOPA
  • HoPan
Molecular Formula
C10H18NO5 • 1/2Ca
Formula Weight
504.6
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
OCC(C)(C)[C@@H](O)C(NCCCC([O-])=O)=O.OCC(C)(C)[C@@H](O)C(NCCCC([O-])=O)=O.[Ca+2]
InChi Code
InChI=1S/2C10H19NO5.Ca/c2*1-10(2,6-12)8(15)9(16)11-5-3-4-7(13)14;/h2*8,12,15H,3-6H2,1-2H3,(H,11,16)(H,13,14);/q;;+2/p-2/t2*8-;/m00./s1
InChi Key
OVXZVDMCQPLHIY-QXGOIDDHSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $88

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    10 mg

    $138

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    50 mg

    $438

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    Cayman Chemical
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    Product Description

    Hopantenate is a derivative of pantothenic acid (Item No. 17288), a biosynthetic precursor of CoA.1 Hopantenate, after phosphorylation by pantothenate kinase (PanK), forms a nonreactive complex with phosphopantothenoylcysteine synthetase (PPCS) that inhibits cellular CoA biosynthesis. Hopantenate induces acute encephalopathy with hepatic steatosis and coma in dogs when administered alone but not when combined with pantothenic acid.2 It reduces electrically induced seizure activity and methylphenidate-induced hyperlocomotion in mice at 2 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mostert, K.J., Sharma, N., van der Zwaag, M., et al. The coenzyme A level modulator hopantenate (HoPan) inhibits phosphopantotenoylcysteine synthetase activity. ACS Chem Biol. 16(11), 2401-2414 (2021).

    2. Noda, S., Haratake, J., Sasaki, A., et al. Acute encephalopathy with hepatic steatosis induced by pantothenic acid antagonist, calcium hopantenate, in dogs. Liver 11(3), 134-142 (1991).

    3. Nishizawa, Y., Kodama, T., and Tsujino, G. Effect of gamma-aminobutyric acid derivatives, especially homopantothenic acid, on the excitability of the brain. J. Vitaminol. (Kyoto) 14(4), 331-344 (1968).