A PROTAC that drives BRD9 degradation
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dBRD9

Item No. 45720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[4-(1,2-dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2,6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-acetamide
CAS Number
2170679-45-3
Molecular Formula
C40H45N7O10
Formula Weight
783.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(NC(CC1)=O)C1N2C(C3=C(C=CC=C3NCCOCCOCCNC(CN(CC4=C(OC)C=C(C5=CN(C)C(C6=C5C=CN=C6)=O)C=C4OC)C)=O)C2=O)=O
InChi Code
InChI=1S/C40H45N7O10/c1-45(21-29-32(54-3)18-24(19-33(29)55-4)28-22-46(2)38(51)27-20-41-11-10-25(27)28)23-35(49)43-13-15-57-17-16-56-14-12-42-30-7-5-6-26-36(30)40(53)47(39(26)52)31-8-9-34(48)44-37(31)50/h5-7,10-11,18-20,22,31,42H,8-9,12-17,21,23H2,1-4H3,(H,43,49)(H,44,48,50)
InChi Key
AIOCFZJGGGEWDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $382

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    10 mg

    $600

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    25 mg

    $1,090

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    Cayman Chemical
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    Product Description

    dBRD9 is a proteolysis-targeting chimera (PROTAC) composed of a bromodomain-containing protein 9 (BRD9) inhibitor conjugated to the cereblon (CRBN) inhibitor pomalidomide (Item No. 19877) via an alkyl ether linker.1 It selectively degrades BRD9 over BRD4 and BRD7 at 100 nM and reduces the proliferation of MOLM-13 leukemia cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Remillard, D., Buckley, D.L., Paulk, J., et al. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Agnew. Chem. Int. Ed. Engl. 56(21), 5738-5743 (2017).