An inhibitor of SPAK
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ZT-1a

Item No. 45727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-benzamide
CAS Number
212135-62-1
Molecular Formula
C22H15Cl3N2O2
Formula Weight
445.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC(Cl)=CC=C1O)NC2=CC(Cl)=C(C(C#N)C3=CC=C(Cl)C=C3)C=C2C
InChi Code
InChI=1S/C22H15Cl3N2O2/c1-12-8-16(18(11-26)13-2-4-14(23)5-3-13)19(25)10-20(12)27-22(29)17-9-15(24)6-7-21(17)28/h2-10,18,28H,1H3,(H,27,29)
InChi Key
RPTKRVXJNWPJLU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $196

    Add

    10 mg

    $294

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    ZT-1a is an inhibitor of STE20/SPS1-related proline-alanine-rich protein kinase (SPAK; IC50 = 46.7 µM in a cell-free assay).1 It reduces phosphorylation of Na-K-Cl cotransporter 1 (NKCC1), Na-K cotransporter 2 (KCC2), and KCC3 in HEK293 cells. ZT-1a reduces cerebrospinal fluid (CSF) hypersecretion in a rat model of post-hemorrhagic hydrocephalus and reduces infarct size, ischemic cerebral edema, and neurological deficit scores in a mouse model of ischemic stroke.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, J., Bhuiyan, M.I.H., Zhang, T., et al. Modulation of brain cation-Cl﹘ cotransport via the SPAK kinase inhibitor ZT-1a. Nat. Commun. 11(1), 78 (2020).