A synovial fibroblast-targeting peptide
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HAP-1 (trifluoroacetate salt)

Item No. 45762

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C60H90N18O17 • XCF3COOH
Formula Weight
1335.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
SFHQFARATLAS-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS pH 7.2: Sparingly soluble: 1-10 mg/ml
SMILES
OC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CN=CN3)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C60H90N18O17.C2HF3O2/c1-30(2)22-41(54(89)69-32(4)49(84)77-45(28-80)59(94)95)76-58(93)47(34(6)81)78-50(85)33(5)68-52(87)39(18-13-21-66-60(63)64)71-48(83)31(3)70-55(90)42(23-35-14-9-7-10-15-35)74-53(88)40(19-20-46(62)82)72-57(92)44(25-37-26-65-29-67-37)75-56(91)43(73-51(86)38(61)27-79)24-36-16-11-8-12-17-36;3-2(4,5)1(6)7/h7-12,14-17,26,29-34,38-45,47,79-81H,13,18-25,27-28,61H2,1-6H3,(H2,62,82)(H,65,67)(H,68,87)(H,69,89)(H,70,90)(H,71,83)(H,72,92)(H,73,86)(H,74,88)(H,75,91)(H,76,93)(H,77,84)(H,78,85)(H,94,95)(H4,63,64,66);(H,6,7)/t31-,32-,33-,34+,38-,39-,40-,41-,42-,43-,44-,45-,47-;/m0./s1
InChi Key
WAIJLJNGNGCPLQ-WJILONSRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    HAP-1 is a synovial fibroblast-targeting peptide.1 It has been conjugated to the antimicrobial peptide (KLAK)2 to generate a pro-apoptotic peptide, which decreases synovial leukocyte infiltration in a rabbit model of rheumatoid arthritis when administered intra-articularly. HAP-1 has also been conjugated to liposomes for the selective delivery of an NF-κB inhibitory peptide to inflamed synovium in a rat model of rheumatoid arthritis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mi, Z., Lu, X., Mai, J.C., et al. Identification of Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synoviuma synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol. Ther. 8(2), 295-305 (2003).