An allosteric activator of mutant POLγ
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PZL-A

Item No. 45767

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(4S)-8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl]-N′-(1-phenyl-1H-pyrazol-3-yl)-urea
CAS Number
3068830-89-4
Molecular Formula
C19H17ClN4O2
Formula Weight
368.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(NC1=NN(C2=CC=CC=C2)C=C1)N[C@H]3CCOC4=C(Cl)C=CC=C43
InChi Code
InChI=1S/C19H17ClN4O2/c20-15-8-4-7-14-16(10-12-26-18(14)15)21-19(25)22-17-9-11-24(23-17)13-5-2-1-3-6-13/h1-9,11,16H,10,12H2,(H2,21,22,23,25)/t16-/m0/s1
InChi Key
BSTIDGXIEVTIMB-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    5 mg

    $162

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    10 mg

    $266

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    25 mg

    $443

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    Product Description

    PZL-A is an allosteric activator of mutant DNA polymerase γ (POLγ), an enzyme frequently mutated in POLG-related mitochondrial disease.1 It stabilizes the interface between the subunits POLγA and POLγB in mutant POLγ and restores polymerase activity with half maximal activity concentration (AC50) values of 0.16 and 0.02 µM for POLγA467T and POLγG848S, respectively. PZL-A restores decreases in mitochondrial DNA (mtDNA) levels induced by ethidium bromide (Item No. 39132) and increases ATP production in fibroblasts isolated from patients with POLγA467T/G848S or POLγW748S/R232H mutations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Valenzuela, S., Zhu, X., Macao, B., et al. Small molecules restore mutant mitochondrial DNA polymerase activity. Nature 642(8067), 501-507 (2025).