A hydrogenated glycerophospholipid
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Phosphatidylcholine (hydrogenated) (soy)

Item No. 45786

Product Insert (PDF)
Technical Information
CAS Number
97281-48-6
Synonyms
  • HSPC
  • Hydro Soy PC
Purity
≥95% (mixture)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
[R]C(OC[C@@H](OC([R])=O)COP([O-])(OCC[N+](C)(C)C)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    25 mg

    $40

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    200 mg

    $160

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    500 mg

    $280

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    1 g

    $480

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    Phosphatidylcholine (hydrogenated) (soy) (HSPC) is a hydrogenated glycerophospholipid derived from natural soy lecithin.1 HSPC has been widely used in the generation of liposomes.2,3,1 HSPC (1.25 wt% in the diet) decreases hepatic total lipid and cholesterol levels in mice fed a high-fat diet.4 Formulations containing HSPC have been used in cosmetic products as skin-conditioning agents and in the generation of liposomes for the delivery of anticancer and antifungal agents. This product contains phosphatidylcholine molecular species with primarily C16:0 and C18:0 fatty acyl chains.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rao, P., Rudrakshula, M., Potham, R., et al. Unified synthesis of DSPC and PSPC: Chemical entities of hydrogenated soy L-α-phosphatidylcholine (HSPC), a key component of liposomal drug formulations. Tetrahedron Lett. 155, 155424 (2025).

    2. Sha, X., Guo, J., Chen, Y., et al. Effect of phospholipid composition on pharmacokinetics and biodistribution of epirubicin liposomes. J. Liposome Res. 22(1), 80-88 (2012).

    3. Son, K., Ueda, M., Taguchi, K., et al. Evasion of the accelerated blood clearance phenomenon by polysarcosine coating of liposomes. J. Control Release 322, 209-216 (2020).

    4. Tandy, S., Chung, R.W., Kamili, A., et al. Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet. Atherosclerosis 213(1), 142-147 (2010).